Molecular Analysis of Radiation Resistance Process in Radioresistant Oesophageal Adenocarcinoma Cells

Background: The radiation resistance process is a major problem in radiotherapy. Proteomics useful method to determine the molecular mechanism of biological and medical events. Protein-protein interaction (PPI) network suitable for proteomics data interpretation. Objectives: Assessment about human cell lines via PPI analysis aim this study. Methods: Proteomic were extracted from literature differentially expressed proteins (DEPs) included STRING database by Cytoscape software. was analyzed central nodes introduced. assessed action map gene ontology enrichment. Results: Among 251 queried DEPs, 171 individuals network. EGFR, FN1, CD44, PTGS2, NFKBIA, KEAP1, CTSD, PHGDH, NT5E introduced as critical DEPs. Eight groups terms attributed PTGS2 discriminated among DEPs key dysregulated proteins. Conclusions: results indicate that are four essential involved radioresistant cells.